Officials claim the prominent El Nadeem centre has breached unspecified health ministry regulations.
But the centre’s director said the decision was “politically motivated”.
Rights group have criticised Egypt’s government for its crackdown on dissent, and there has been a surge in allegations of torture by officials.
The Cairo-based El Nadeem centre has been in operation since 1993, providing support and counselling to victims of torture.
Aida Seif al-Dawla, the organisation’s director, said the group has been given until Monday to close but vowed to defy the order.
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